Immune Response

 

An Effective Immune Response Is Specific, Adaptable, and Durable1,2

SPECIFIC

Immunotherapy treatment activates T cells and B cells that target specific tumor antigens3-5

  • The activated immune system is primed to recognize tumor
    antigens expressed by each patient's unique and frequently
    changing population of cancer cells3
  • Some activated T cells kill tumor cells directly or indirectly3
  • Some activated T cells activate B cells, which become antibody-producing plasma cells3

Learn more by watching
Immunotherapy Is
Tumor-Specific
(2:10)

Immunotherapy Is Tumor-Specific

ADAPTABLE

Immunotherapy treatment is designed to support the immune system's ability to adapt its attack over time3,5-8

  • Each patient's population of tumor cells mutates over time, which may result in resistance to traditional anticancer therapies3
  • When a tumor cell is killed, additional antigens are released, stimulating activation of new populations of T cells and B cells
    that recognize tumor antigens3,4,6,7
  • This can result in an expanding cascade of immune cells able to recognize cancer cells bearing a variety of tumor antigens as the tumor mutates over time5-8

Learn more by watching
Immunotherapy Is Designed to
Support Immune System Adaptability

(2:43)

Immunotherapy Is Designed to Support Immune System Adaptability

DURABLE

Immunotherapy treatment stimulates immunologic memory, which
may lead to a prolonged antitumor response3,9-10

  • Some activated immune cells become memory cells, which remain primed to stimulate an immune response when tumor cells bearing target antigens are encountered within the body3,9-10

Learn more by watching
Immunotherapy Empowers a
Durable Immune Response

(2:16)

Immunotherapy Empowers a Durable Immune Response

 

There Are 3 Key Cells Involved in Immune Response

A natural immune response involves 3 different types of cells1:

  • Antigen Presenting Cells (APCs) identify and uptake foreign antigens to present them to T cells

    Antigen Presenting Cells
  • T cells are activated by APCs to recognize and destroy cells containing foreign antigens

    T cells
  • B cells produce antibodies specific to foreign antigens

    B cells
 

Initiation of Natural Immune Response: Key Cells1

Initiation of Natural Immune Response: Key Cells – Fight Cancer with Immunotherapy

Adapted from Abbas AK, et al.1

Learn More About Immunotherapy and Cancer