State of Cancer Immunotherapy

 

Immunotherapy Has a Long History1-5

Immunotherapy has been under evaluation for more than a century, but only recently has it entered a renaissance phase with approval of multiple agents for the treatment of cancer.
History of Immunotherapy – Fight Cancer with Immunotherapy

Adapted with permission from Lesterhuls WJ, et al2 and Kirkwood JM, et al. J Clin Oncol. 2008;26(20):3445-3455.
BCG=Bacillus Calmette-Guérin; CA=cancer

 
FDA-Approved Immunotherapies*,1,4,6-8
Class Approvals
Monoclonal antibodies 1997, 1998, 2000, 2001, 2002, 2003, 2004, 2006, 2009
Checkpoint inhibitor 2011
Cytokines 1986, 1992, 1995,
1998
Therapeutic vaccine 2010
*Not inclusive of all immunotherapy classes.
 

The Future of Immunotherapy

Clinical research in immunotherapy is rapidly increasing:

  • From 2009 to 2012, abstracts at major conferences have doubled9
  • There are approximately 800 ongoing clinical trials in various phases for cancers such as breast, colon, head and neck, and kidney10

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